2253 BCL-2 expression in choroidal melanoma

2253 BCL-2 expression in choroidal melanoma

Purpose: Lympboprolifcrativc ocular adnexal lesions represent 1 spectrum of disorders which range from reactive lymphoid hyperplasia to malignant lymphoma and include lewas which ared an mddcrminatc nature morphologrccally and immunophenotypically. Futhmnwe cases have been ckcvmented where progresswn from reactix hyperplasia to frank Ippboma has camed. We have applied molecular genetIc te&lques...

Analysis of Bcl-2 protein expression in choroidal melanomas.

BACKGROUND Bcl-2 protooncogene alterations are involved in tumorigenesis and may have prognostic ramifications. AIMS To investigate normal ocular structures and choroidal melanoma for: (1) Bcl-2 protein expression (semiquantitative staining values: SI, staining intensity; PP, percentage of positive cells; and IRS, immunoreactivity score) and (2) any associations between the staining values an...

Expression and Function of Bcl-2 Proteins in Melanoma

Bcl-2 proteins are critical regulators of mitochondrial membrane permeability and the proapoptotic mitochondrial pathway. The family encloses pro- and antiapoptotic factors encoded by over 15 genes, which frequently give rise to alternative splice products. Antiapoptotic, proapoptotic multidomain, and proapoptotic BH3-only proteins are characterized by the presence of at least one of four Bcl-2...

PTEN expression in melanoma: relationship with patient survival, Bcl-2 expression, and proliferation.

PURPOSE Inactivation of the tumor suppressor gene, phosphatase and tensin homologue (PTEN), is a major alteration in preclinical melanoma models. We investigated the clinical relevance of PTEN expression in the primary melanoma patients with extended follow-up. EXPERIMENTAL DESIGN We correlated PTEN expression with clinicopathologic variables and outcome in 127 primary melanomas (median follo...

Choroidal Melanoma